Mastering Science Work-Textbook Secondary 3B is developed based on the B.E. 2560 (A.D. 2017) revised version of Thailand’s Basic Education Core Curriculum B.E. 2551 (A.D. 2008). It includes active learning activities to engage the students in the learning process which helps them learn meaningfully and enhance their thinking skills. It also provides opportunities for students to conduct activities and experiments using the scientific process. Finishing with integrated activity, it helps boost students’ STEM skills.